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Jobs

Postdoc Position Available - Myc regulated lncRNAs in B-cell lymphoma

 

Department Department of Pathology & Medical Biology
Work location Groningen
Apply no later than 14 September 2024

lncRNAWorking environment

Project description
Our lab is interested in understanding the function of non-coding RNAs in B-cell lymphoma. Besides studying microRNAs for over ten years, we more recently gained interest in the function of long non-coding RNAs in B cell lymphoma. Long non-coding RNAs are an exciting group of transcripts involved in many cell physiological processes, and deregulation of them has been associated with many diseases such as cancer. One of the important oncogenes in B-cell lymphoma is the transcription factor Myc that is known to regulate expression of a large number of genes that are important for malignant transformation. Using a comprehensive gene expression analysis approach, we recently identified a group of Myc-regulated long non-coding RNAs. The objective of this project funded by the pediatric oncology foundation Groningen (SKOG) is to determine to what extend these long non-coding RNAs are involved in the pathogenesis of Myc-associated B-cell lymphoma and to unveil the underlying mechanisms.

Our Research group is located at the Department of Pathology & Medical Biology and we have close collaborations with the Departments of Genetics and Hematology. The research line is embedded within the Cancer Research Center Groningen. The focus of this research center is to initiate and stimulate the translation of fundamental insights from preclinical research programs on oncogenesis and tumor behavior into cancer prevention, improvement of early detection of cancer and better treatment for cancer patients. The non-coding B cell lymphoma group is part of the Stem cells Aging, Leukemia and Lymphoma (SALL) subprogram which includes various research groups of the Hematology, Stem cell biology, Pediatric oncology and Pathology. Besides an excellent international scientific environment we have state-of-the-art research facilities including those needed for NGS, imaging, qRT-PCR, array analysis and many others.

What do we need

  • PhD in molecular biology, cancer research or equivalent.
  • You are an outstanding enthusiastic scientist who is pro-active, independent and motivated to setup assays to mechanistically study lncRNAs.
  • You are a team player and aim to pursue a career in scientific research.
  • You have experience with diverse molecular biology techniques and bioinformatics analysis is a strong advantage.
  • You have excellent English skills, both oral and written.
  • Experience in writing scientific papers and presentation of your work at scientific meetings.
  • Experience in supervision of students and technicians.
  • Fascination for non-coding RNA is an advantage.

The UMCG has a preventive Hepatitis B policy. You may be required to build up sufficient protection against Hepatitis B before you can be appointed. Vaccination is provided by the UMCG if necessary.

What do we offer

  • A postdoc position according to conditions of employment that comply with the Collective Labor Agreement for Medical Centers (CAO-UMC).
  • A contract for one year with a second year extension after positive evaluation.
  • Based on qualifications and experience a maximum salary of € 4.070,- gross a month (scale 10) for a fulltime position.

More information
For more information about this vacancy you may contact:
Mr. Dr. J. Kluiver, molecular biologist, phone: +31 50 3615788, email: j.l.kluiver@umcg.nl (please do not use for applications).
Ms. Prof. dr. A. van den Berg, molecular biologist, phone: +31 50 3611476, email: a.van.den.berg01@umcg.nl (please do not use for applications).

Applying for a job

Please use the the digital application form at the bottom of this page - only these will be processed.
You can apply until 14 September 2024.
Immediately after sending the digital application form you will receive an email- confirmation with further information.
(Learn more…)

Apply

Postdoc Position Available - University of Copenhagen

Deadline for application is September 22, 2024

The fellowship is part of a newly established European non‐coding RNA training network, ‘RNatrain’ funded by th European Commission as a Marie Curie Initial Training Network (FP7). We are looking for a researcher to join the programme and the Lund Group at BRIC from January 1st 2015 or after agreement. (find out more…)

Postdoc position available - non-coding RNA research at BRIC, University of Copenhagen

lncRNAA postdoc position (experienced researcher) is available in the Lund Group at BRIC from October 1st 2014. The position is part of a newly established European non-coding RNA training network, RNAtrain under the FP7 frame programme.

The group
The Lund group is an international and dynamic research group comprising several postdocs, PhD students and Masters students. Research in the Lund group currently has several focuses including the function and regulation of microRNAs and long non-coding RNAs in human diseases.

Please read more about the Lund Research Group and BRIC on www.bric.ku.dk

Area of Research
The successful candidate will use mouse models to investigate the functional importance of non-coding RNAs (ncRNAs) implicated in cancer-related pathways. We have performed expression profiling studies of non-coding RNAs in several human cancers and cancer-related cell culture models, such as DNA damage, autophagy and senescence. Based on these studies, a number of ncRNAs are currently being functionally investigated and we wish to further explore a subset of these in knockout or xenograft mouse models. The institute is fully equipped for animal experimentation, including in vivo imaging and flow cytometry. Previous experience with such techniques would be a strong benefit to the applicant.

Post-doc position available - Computational lncRNA Genomics

lncRNA

Postdoctoral Research Scientist - Computational lncRNA Genomics
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, Oxford
Grade 7: £29,837 - £36,661 with a discretionary range to £38,907 p.a.
We are seeking a highly motivated and enthusiastic postdoctoral scientist to join Professor Chris Ponting’s research group in the internationally renowned MRC Functional Genomics Unit at the University of Oxford. This 1 year post is ideal for a newly graduated scientist who is seeking computational RNA biology experience before specialising in one area of genomics.You will join Professor Ponting’s Computational Genomics group that has established an international reputation for genome-scale data analyses, disease genomics, and function prediction for coding or non-coding sequence. The post will provide core biological and computational expertise in lncRNA genomics and in next-generation sequence analysis to a large experimental group working on lncRNAs.

With a PhD/DPhil in the field of computational biology, bioinformatics, statistical genetics or comparative genomics, experience of scripting (e.g. Perl/Python), advanced UNIX and administering a Linux system are essential. Expertise in sequence analysis tools in biological research, current bioinformatics tools and resources, functional genomics and method development will also be desirable. Excellent organisational and communication skills will be required, together with the ability to work well within a team.

You will work in the MRC Unit within the Department of Physiology, Anatomy and Genetics at the University of Oxford. The Functional Genomics Unit is a world-renowned centre for comparative genomics and research into neurological disorders. We offer excellent computational and laboratory facilities in the Henry Wellcome Building of Gene Function. Informal enquiries can be made to Professor Chris Ponting.

The closing date for applications is 12.00 midday on 6 June 2014. Interviews are likely to be held on 18 or 20 June 2014.

Contact Person : HR at DPAG Vacancy ID : 112813
Contact Phone : 01865 272411 Closing Date : 06-Jun-2014
Contact Email : recruitment@dpag.ox.ac.uk
Click on the link(s) below to view documents Filesize
AV14023 (112813) PDRS Ponting Further Particulars 93.5

(find out more…)

Postdoctoral fellow in Epigenetics and long noncoding RNAs (lncRNAs)

Goteborg University (PER 2014/201)

lncRNATitle
Postdoctoral fellow in Epigenetics and long noncoding RNAs (lncRNAs) (PER 2014/201)
Advertiser
Goteborg University
Role
Postdoctoral Research Fellow
Discipline
Medicine & Health
Location
Gothenburg, Sweden
Work Type
Full Time, Fixed Term, 2 years

Extent: 100 %
Location: Institute of Biomedicine, Göteborg
First day of employment: As agreed
Reference number: PER 2014/201

The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them.