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Long non-coding RNAs in the cardiovascular system

Dr. Stefanie Dimmeler - Dr. Reinier Boon - Katharina M. Michalik Katharina Michalik, Reinier Boon and Stefanie Dimmeler work at the Institute for Cardiovascular Regeneration at the Goethe University in Frankfurt, Germany. They are interested in microRNAs and long non-coding RNAs (lncRNAs) that control cardiovascular functions in endothelial cells. What is the background for your current project involving LNA™ GapmeRs? ...

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RNAi Screens and the Reagents That Enable Them

from Genetic Engineering News 2013 (Vol. 33, No. 19) by Jeanene Swanson RNAi screens for functional genomics typically look for loss- or gain-of-function phenotypes. They currently have many applications, including target discovery and validation, lead identification and optimization, mechanism of action discovery, predictive toxicology, and biomarker identification. While reagents are gaining ground, technical difficulties remain in how best to perform ...

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Request for feedback on nomenclature of antisense bidirectional long non-coding RNA genes

The HUGO Gene Nomenclature Committee (HGNC) is the organisation responsible for naming human genes. In their current newsletter (http://www.genenames.org/hgncnews/hgnc-newsletter-summer-2013) they are asking the research community how they would like them to name bidirectional antisense lncRNA genes. It would be best if they could get feedback from as many interested lncRNA researchers as possible, so please check out the newsletter and ...

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LncRNA: Why and How to Study it?

Introduction Long non-coding RNAs (LncRNAs) are evolutionarily conserved, longer than 200nt, non-coding RNA molecules found in eukaryotes. Growing evidence suggests that LncRNAs have emerged as important regulators for diverse functions1. LncRNAs are involved in a surprisingly wide variety of cellular functions, including epigenetic silencing, transcriptional regulation, RNA processing, and RNA modification2. In addition, LncRNAs have been associated with human diseases ...

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Science Gone Social

by Tracy Vence at Genetic Engineering News.com From keeping up with the literature to sparking collaborations and finding funds, scientists are storming social media. Not many scientists have produced manuscripts as a direct result of participating in discussions on social media. Fewer still support their research programs in full by funds obtained in the same way. But, respectively speaking, Emily ...

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Molecular Biology of Long Non-coding RNAs

Khalil, Ahmad M.; Coller, Jeff (Eds.) 2014, VI, 166 p. 18 illus., 16 illus. in color. ISBN 978-1-4614-8620-6 About this book ​​Brings together key experts in the field of lncRNAs Has appeal for basic scientists and clinicians Focuses on the recently discovered, and less understood, class of long non-coding RNAs Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm ...

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What are lncRNAs?

from Exiqon.com It was traditionally thought that the transcriptome would be mostly comprised of mRNAs, however advances in high-throughput RNA sequencing technologies have revealed the complexity of our genome. Non-coding RNA is now known to make up the majority of transcribed RNAs and in addition to those that carry out well-known housekeeping functions (e.g. tRNA, rRNA etc), many different types ...

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LncRNA Expression Microarray Platform: Gencode v15

We have created a custom lncRNA expression array design (gencode.v15.lncrna.2probe.version1) with probes targeting the Gencode v15 human lncRNA annotation. The design file is for the standard Agilent 8x60k expression array format, with two 60mer probes targeting each of 22,001 lncRNA transcripts. The array also contains 17,535 catalogue probes targeting protein-coding genes. Similar arrays designed against an earlier version of Gencode ...

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The Rise of lncRNAs Timeline

from Epigenie.com Long non-coding RNAs, also known as lncRNAs, are gaining a truck load of momentum in the field of the epigenetics. Here we highlight the hottest research, methods papers, and the occasional interview centered around these long and curvy regulatory RNAs. (read more…)

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