Long noncoding RNAs represent a large class of transcripts with two common features: they exceed an arbitrary length threshold of 200 nt and are assumed to not encode proteins. Although a growing body of evidence indicates that the vast majority of lncRNAs are potentially nonfunctional, hundreds of them have already been revealed to perform essential gene regulatory functions or to ...
Read More »LDNFSGB - prediction of long non-coding rna and disease association using network feature similarity and gradient boosting
A large number of experimental studies show that the mutation and regulation of long non-coding RNAs (lncRNAs) are associated with various human diseases. Accurate prediction of lncRNA-disease...
Read More »DeepCNPP - deep learning architecture to distinguish the promoter of human long non-coding RNA genes and protein-coding genes
Promoter region of protein-coding genes are gradually being well understood, yet no comparable studies exist for the promoter of long non-coding RNA..
Read More »IDHI-MIRW - prediction of lncRNA-disease associations by integrating diverse heterogeneous information sources
Long non-coding RNAs play an important role in human complex diseases. Identification of lncRNA-disease associations will gain insight into disease-related lncRNAs and benefit disease diagnoses and...
Read More »Profiling Therapeutically Actionable Long Non-coding RNAs Using CRISPR-Cas9 Screening
Long non-coding RNAs (lncRNAs) represent a huge reservoir of potential cancer targets. Such "onco-lncRNAs" have resisted traditional RNAi methods, but CRISPR-Cas9 genome editing now promises functional screens at high throughput and low cost....
Read More »CisPi - a transcriptomic score for disclosing cis-acting disease-associated lincRNAs
Long intergenic noncoding RNAs (lincRNAs) have risen to prominence in cancer biology as new biomarkers of disease. Those lincRNAs transcribed from active cis-regulatory elements (enhancers) have provided mechanistic insight into cis-acting...
Read More »UPA-Seq - prediction of functional lncRNAs using differential sensitivity to UV crosslinking
While a large number of long noncoding RNAs (lncRNAs) are transcribed from the genome of higher eukaryotes, systematic prediction of their functionality has been challenging due to the lack of conserved sequence motifs or structures...
Read More »LncFinder - an integrated platform for long non-coding RNA identification
Discovering new long non-coding RNAs (lncRNAs) has been a fundamental step in lncRNA-related research. Nowadays, many machine learning-based tools have been developed for lncRNA identification. However, many methods predict lncRNAs using sequence-derived features alone, which tend to display unstable performances on different species. Moreover, the majority of tools cannot be re-trained or tailored by users and neither can the features ...
Read More »LncPipe - A Nextflow-based pipeline for identification and analysis of long non-coding RNAs from RNA-Seq data
Recently, long noncoding RNA molecules (lncRNA) captured widespread attentions for its critical roles in diverse biological process and important implications in variety of human diseases and cancers...
Read More »Identification of transcribed protein coding sequence remnants within lincRNAs
Long intergenic non-coding RNAs (lincRNAs) are non-coding transcripts >200 nucleotides long that do not overlap protein-coding sequences. Importantly, such elements are known to be tissue-specifically expressed and to play a widespread role in gene...
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