Search Results for: fendrr grote et al 2013
Featured long non-coding RNA - Fendrr
The histone-modifying complexes PRC2 and TrxG/MLL play pivotal roles in determining the activation state of genes controlling pluripotency, lineage commitment, and cell differentiation. Long noncoding RNAs (lncRNAs) can bind to either complex, and some have been shown to act as modulators of PRC2 or TrxG/MLL activity.
Now, researchers at Max Planck Institute for Molecular Genetics, Germany show that the lateral mesoderm-specific lncRNA Fendrr is essential for proper heart and body wall development in the mouse. Embryos lacking Fendrr displayed upregulation of several transcription factors controlling lateral plate or cardiac mesoderm differentiation, accompanied by a drastic reduction in PRC2 occupancy along with decreased H3K27 trimethylation and/or an increase in H3K4 trimethylation at their promoters. Fendrr binds to both the PRC2 and TrxG/MLL complexes, suggesting that it acts as modulator of chromatin signatures that define gene activity. Thus, they have identified Fendrr as an lncRNA that plays an essential role in the regulatory networks controlling the fate of lateral mesoderm derivatives.
Grote P et al. (2013) The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse. Cell [Epub ahead of print]. [article]
More on this breakthrough…
http://phys.org/news/2013-01-epigenetic-cardiogenesis-non-coding-rna-essential.html
http://www.sciencedaily.com/releases/2013/01/130129100247.htm
Incoming search terms:
- long noncoding rnas in cardiac development and pathophysiology
- fendrr long ncRNA