Search Results for: lncrna classes
lncRNA Market Trends - Learn the latest about the expanding and evolving long noncoding RNA space.
from Genetic Engineering News by Enal Razvi, Ph.D.
The focus of this GEN Market & Tech Analysis report is to present some of our recent industry tracking of the long noncoding RNA (lncRNA) space, as this space is expanding and evolving.Highlights of this report:
- The lncRNA space is expanding and the numbers of lncRNA sequences deposited in the biological databases is increasing.
- However, the function of these lncRNAs is speculative currently; there is belief that they may be involved in epigenetic regulation of the genome and perhaps other functions in vivo as well.
- One of the emerging themes that is appearing is that lncRNAs may have potential as circulating biomarkers (as they are beginning to be identified and studied in biological fluids), primarily in cancer but perhaps also in other disease classes.
- Even though the microRNA field is much larger today and encompasses more segments (such as diagnostics and therapeutics development), lncRNAs must not be discounted and they may indeed hold diagnostic value—their sheer number in the genome suggests important biological roles.
lncRNAs and Epigenetic Modulations: Potential Hotspots
from Genetic Engineering News
Market and Technology Analysis
The focus of this GEN Market & Tech Analysis report is to present a snapshot of regional epigenetic down- and up-regulation in cancer with a focus toward prostate cancer.
We present here long-range epigenetic silencing (LRES) as a means for downregulation of stretches of the genome as well as long-range epigenetic activation (LREA). These two opposing effects appear to be mediated by an interplay between DNA methylation and chromatin modification. We’ve focused this analysis on an interrogation of prostate cancer.
Regional Epigenetic Down- and Up-Regulation in Cancer & lncRNAs with Potential Functionality
The focus of this GEN Market & Tech Analysis report is to present a snapshot of regional epigenetic down- and up-regulation in cancer with a focus toward prostate cancer.
We present here long-range epigenetic silencing (LRES) as a means for downregulation of stretches of the genome as well as long-range epigenetic activation (LREA). These two opposing effects appear to be mediated by an interplay between DNA methylation and chromatin modification. We’ve focused this analysis on an interrogation of prostate cancer.
Also presented herein are potential associations of long noncoding RNAs (lncRNAs) with distinct cancer classes. The potential utility of lncRNAs in finely modulating the expression of distinct regions of the genome makes this class of molecules attractive potential biomarkers and perhaps even therapeutic targets in the future.
lncRNA space could be twice as big as the miRNA space
from Genetic Engineering News by Enal Razvi, Ph.D.
Long Noncoding RNAs: Why You Need to Know about Them Now
lncRNA space could be twice as big as the miRNA space as they seem to have tremendous potential as disease biomarkers.
The focus of this GEN Market & Tech Analysis Report is to present some of our recent industry tracking of the long noncoding RNAs (lncRNAs) space as a follow-on to the GEN Report on microRNA Associations and Signatures.
In this report, we present the following:
- Frame the position of lncRNAs vis-à-vis other classes of RNAs
- Current breakout of the research marketplace as to which segments of research activity on lncRNAs are being focused upon
- Publication analysis of the key lncRNAs across different disease classes
A key driver for the interest in lncRNAs is their sheer number in the genome (tens of thousands of lncRNAs are believed to exist) and the multitude of roles they are believed to play including structural roles, modulation/fine-tuning of gene expression in vivo, and epigenetic effects. Indeed, some lncRNAs have been associated with cancer and a few reports even suggest the possibility of lncRNAs with biomarker potential.
LRLSLDA: Laplacian Regularized Least Squares for LncRNA-Disease Association
More and more evidences have indicated that long-non-coding RNAs (lncRNAs) play critical roles in many important biological processes. Therefore, mutations and dysregulations of these lncRNAs would contribute to the development of various complex diseases. Developing powerful computational models for potential disease related lncRNAs identification would benefit biomarker identification and drug discovery for human disease diagnosis, treatment, prognosis and prevention.
In this paper, researchers from the Chinese Academy of Sciences, P.R. China have proposed the assumption that similar diseases tend to be associated with functionally similar lncRNAs. Then, they further developed the method of Laplacian Regularized Least Squares for LncRNA-Disease Association (LRLSLDA) in the semi-supervised learning framework. Although known disease-lncRNA associations in the database are rare, LRLSLDA still obtained an AUC of 0.7760 in the leave-one-out cross validation, significantly improving the performance of previous methods. They also illustrated the performance of LRLSLDA is not sensitive (even robust) to the parameters selection and it can obtain a reliable performance in all the test classes. Plenty of potential disease-lncRNA associations were publicly released and some of them have been confirmed by recent results in biological experiments. It is anticipated that LRLSLDA could be an effective and important biological tool for biomedical research.
AVAILABILITY: The code of LRLSLDA is freely available at http://asdcd.amss.ac.cn/Software/Details/2
CONTACT: xingchen@amss.ac.cn
Chen X, Yan GY. (2013) Novel human lncRNA-disease association inference based on lncRNA expression profiles. Bioinformatics [Epub ahead of print]. [abstract]