Scientists recently reported the key role of histone acetylation-regulated long noncoding RNA termed as lysosome cell death regulator (LCDR) in tumor survival, providing a potential diagnostic and therapeutic target for lung cancer.Led by Prof. GAO Shan...
Read More »lncRNA-based therapy cures lung cancer in mouse models
By turning down the activity of a specific RNA molecule, researchers at Sahlgrenska Academy, Sweden, have cured lung tumors in mice by 40-50 percent. The results, published in Nature Communications, represent the tip of the iceberg in an extensive research project in which 633 new biomarkers for 14 types of cancer have been identified. A research group led by Chandrasekhar Kanduri, professor ...
Read More »An epigenomic approach to identifying differential overlapping and cis-acting lncRNAs
Long noncoding RNAs (lncRNAs) are critical regulators of cell biology whose alteration can lead to the development of diseases such as cancer. The potential role of lncRNAs and their epigenetic regulation in response to platinum treatment are largely unknown. Researchers at La Paz University Hospital analyzed four paired cisplatin-sensitive/resistant non-small cell lung cancer and ovarian cancer cell lines. The epigenetic landscape ...
Read More »Intersecting transcriptomic profiling technologies and long non-coding RNA function in lung adenocarcinoma
Previously thought of as junk transcripts and pseudogene remnants, long non-coding RNAs (lncRNAs) have come into their own over the last decade as an essential component of cellular activity, regulating a plethora of functions within multicellular organisms. lncRNAs are now known to participate in development, cellular homeostasis, immunological processes, and the development of disease. With the advent of next generation ...
Read More »lncRNAs LOC146880 and ENST00000439577 may promote the progression of NSCLC
To identify what long non-coding RNAs (lncRNAs) are involved in non-small cell lung cancer (NSCLC), researchers from the Shanghai Jiao Tong University School of Medicine analyzed microarray data on gene expression and methylation. Gene expression chip and HumanMethylation450BeadChip were used to interrogate genome-wide expression and methylation in tumor samples. Differential expression and methylation were analyzed through comparing tumors with adjacent ...
Read More »Lung Cancer Research Foundation Awards Grant to lncRNA Researcher
The Lung Cancer Research Foundation (LCRF™) announced the awardees of its 2016 Scientific Grant Program at the Eleventh Annual Lung Cancer Awareness Luncheon, held on Monday, October 17, at The Pierre in New York City. In another record-breaking year, LCRF awarded $2.2 million in research grants to 15 researchers as part of the LCRF Scientific Grant Program, an annual program ...
Read More »Meta analysis of GWAS datasets reveals lung cancer risk lncRNA variant
Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. Duke University School of Medicine researchers performed a large-scale meta-analysis of 690,564 SNPs in 15,531 autosomal lncRNAs by using datasets from six previously published genome-wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium ...
Read More »Long noncoding and circular RNAs in lung cancer
Better understanding and management of lung cancer are needed. Although much has been learned from known protein coding genes, long noncoding RNAs (lncRNAs), a relatively new and fast evolving large family of transcripts, have recently generated much attention for new discoveries. LncRNAs play critical regulatory functions and are emerging as new players in tumorigenesis and phenotypic determinators of lung cancer. ...
Read More »Functional annotation of noncoding variants and prioritization of cancer-associated lncRNAs in lung cancer
Multiple computational tools have been widely applied to the detection of coding driver mutations in cancer; however, the prioritization of pathogenic non-coding variants remains a difficult and demanding task. The present study was performed to distinguish non-coding disease-causing mutations from neutral ones, and to prioritize potential cancer-associated long non-coding RNAs (lncRNAs) with a logistic regression model in lung cancer. A ...
Read More »The Emerging Role and Promise of Long Noncoding RNAs in Lung Cancer Treatment
Lung cancer is the leading cause of cancer death around the world. The advanced discovery of numerous long noncoding RNAs (lncRNAs) has dramatically changed the understanding of biology of human cancers, including lung cancer. LncRNAs are a group of noncoding RNAs (ncRNAs) with a length greater than 200 nucleotides with limited or no protein-coding capacity. Increasing evidence has shown that ...
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