Tag Archives: non-coding rna

Featured lncRNA Job - Scientist II, Translational Medicine Job

lncRNA

Celgene

Job Title:
Job ID: 14273
Location: San Francisco, CA
Offsite Territory:
Full/Part Time: Full-Time
Regular/Temporary: Regular
Category: Research
Department: Translational Medicine - 3268

Celgene Corporation is committed to delivering innovative therapies designed to improve the lives of patients worldwide. We are a global biopharmaceutical company with operations in more than 70 countries that is helping to turn incurable cancers into chronic, manageable conditions. We are seeking talented professionals as we continue to grow and advance our efforts in oncology, hematology and immune and inflammatory disease. If you would like to join a company where you can make a difference, please consider the Celgene family.

Prerequisites:

- PhD with 2-4 years experience in a field of cell biology, biochemistry, or pharmacology.
- Minimum of 2 years post-graduate research experience.

Summary:

The successful candidate will have in-depth knowledge of nucleic acid biochemistry, protein synthesis, and cancer biology, with excellent laboratory technical skills in areas of cell and molecular biology. Unique expertise in the biology of microRNA and/or long non-coding RNA

DETR’PROK: detection of ncRNAs in prokaryotes

RNA-seq experiments are now routinely used for the large scale sequencing of transcripts. In bacteria or archaea, such deep sequencing experiments typically produce 10-50million fragments that cover most of the genome, including intergenic regions. In this context, the precise delineation of the non-coding elements is challenging. Non-coding elements include untranslated regions (UTRs) of mRNAs, independent small RNA genes (sRNAs) and transcripts produced from the antisense strand of genes (asRNA).

Now, researchers at Paris-Sud University have developed present a computational pipeline (DETR’PROK: detection of ncRNAs in prokaryotes) based on the Galaxy framework that takes as input a mapping of deep sequencing reads and performs successive steps of clustering, comparison with existing annotation and identification of transcribed non-coding fragments classified into putative 5′ UTRs, sRNAs and asRNAs. They provide a step-by-step description of the protocol using real-life example data sets from Vibrio splendidus and Escherichia coli.

Availability: The DETR’PROK pipeline is obtained from the Galaxy main tool shed (http://toolshed.g2.bx.psu.edu/)

  • Toffano-Nioche C, Luo Y, Kuchly C, Wallon C, Steinbach D, Zytnicki M, Jacq A, Gautheret D. (2013) Detection of non-coding RNA in bacteria and archaea using the DETR’PROK Galaxy pipeline. Methods [Epub ahead of print]. [article]

Incoming search terms:

  • lncRNA pipeline

Non-coding RNAs in Alzheimer’s disease

lncRNA

Alzheimer’s disease (AD) is a complex neurodegenerative disorder and the most common dementia among the elderly. Accumulating research indicates that noncoding RNAs (ncRNAs), especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are increasingly being implicated in AD. MiRNAs are conserved small ncRNAs that control gene expression post-transcriptionally while lncRNAs function in many ways. Recent profiling research in human or mouse models suggests that miRNAs are aberrantly expressed in AD, and these have been implicated in the regulation of amyloid-β (Aβ) peptide, tau, inflammation, cell death, and other aspects which are the main pathomechanisms of AD. In addition, regulation of miRNAs varies in blood, and cerebral spinal fluid may indicate alterations in AD. Together with brain-specific miRNAs, these miRNAs could be potential AD biomarkers. All the above may provide the basis for new approaches for AD. Here, the authors review current findings regarding ncRNA research in human and mouse models to provide a strong basis for future study aiming at promising contributions of ncRNA in AD.

  • Tan L, Yu JT, Hu N, Tan L. (2013) Non-coding RNAs in Alzheimer’s disease. Mol Neurobiol 47(1), 382-93. [abstract]

Incoming search terms:

  • lncrna regulation of rrna synthesis in blood

NHGRI to Unveil Funding for Tools to Interpret Non-coding Genomic Regions

NHGRI

from GenomeWeb

NEW YORK (GenomeWeb News) – The National Human Genome Research Institute plans to launch a grant program that would fund efforts to develop innovative computational approaches for interpreting variants found in the non-protein-coding regions of the human genome.

NHGRI’s advisory board yesterday approved the program, which will provide up to $500,000 per year to each of five or six projects to create new tools that will pare down the numbers of genomic variants that are thought to be contributing to diseases or other traits.

At its tri-annual meeting yesterday, the National Advisory Council for Human Genome Research agreed that the RFA program, “Interpreting Variation in Human Non-coding Genomic Regions Using Computational Approaches,” should proceed, and the plan now is for the first RFAs to be released in August…

Non-coding RNA Post-Doc position available

Job Summary

Post-Doc Fellow/Research Associate
Job Code: 76_195473
POSTED: Apr 25
Salary: Open Location: Detroit, Michigan
Employer: Wayne State University Type: Full-time
Organization Type: Higher Education Institution Category: Medical - Clinical

Job Description

Essential Functions: Assisting with transcriptional and post-transcriptional control of cell signaling in the immune system under physiological and pathological situations. Working with both human derived cells and stable cell line. Elucidate the role of microRNAs and other non-coding RNAs in immunity and integrate novel post-transcriptional circuits with well established signaling and transcriptional network.Other research duties as assigned.

Qualifications: Ph.D. in Immunology, Microbiology, Pathology, Biochemistry or related fields. Ability to design and execute experiments using conventional molecular biological techniques including analyzing RNA-seq and ChIP-seq data.Ability to work independently and critical thinking abilities. Outstanding communications skills both written and verbal.

Employer Information

About Wayne State University

Founded in 1868, Wayne State University is a nationally recognized metropolitan research institution offering more than 400 academic programs through 13 schools and colleges to nearly 32,000 students. Wayne State?s main campus in Midtown Detroit comprises 100 buildings over nearly 200 acres; its five extension centers offer higher education to people throughout Southeast Michigan. Wayne State is dedicated to preparing students to excel by combining the academic excellence of a major research university…(find out more…)

View All Our Jobs