Long non-coding RNA (lncRNA) is a large class of gene transcripts with regulatory functions discovered in recent years. Many more are expected to be revealed with accumulation of RNA-seq data from diverse types of normal and diseased tissues...
Read More »Identification and prioritization of long non-coding RNAs associated with autism
Genetic studies have identified many risk loci for autism spectrum disorder (ASD) although causal factors in the majority of cases are still unknown. Currently, known ASD risk genes are all protein-coding genes; however, the vast majority of transcripts in humans are non-coding RNAs (ncRNAs) which do not encode proteins. Recently, long non-coding RNAs (lncRNAs) were shown to be highly expressed ...
Read More »ExInAtor - driver lncRNA discovery using mutational patterns in tumour DNA
Long noncoding RNAs (lncRNAs) represent a vast unexplored genetic space that may hold missing drivers of tumourigenesis, but few such “driver lncRNAs” are known. Until now, they have been discovered through changes in expression, leading to problems in distinguishing between causative roles and passenger effects. Researchers at the CRG - Barcelona Institute of Science and Technology have developed a different ...
Read More »ExInAtor - driver lncRNA discovery using mutational patterns in tumour DNA
Long noncoding RNAs (lncRNAs) represent a vast unexplored genetic space that may hold missing drivers of tumourigenesis, but few such “driver lncRNAs” are known. Until now, they have been discovered through changes in expression, leading to problems in distinguishing between causative roles and passenger effects. Researchers at the Barcelona Institute of Science and Technology have developed a different approach for ...
Read More »Annocript - a flexible pipeline for the annotation of transcriptomes also able to identify putative long noncoding RNAs
The eukaryotic transcriptome is composed of thousands of coding and long noncoding RNAs (lncRNAs). However, we lack a software platform to identify both RNA classes in a given transcriptome. Here researchers from the Anton Dohrn - Zoological Station introduce Annocript, a pipeline which combines the annotation of protein coding transcripts with the prediction of putative lncRNAs in whole transcriptomes. It ...
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